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Ulceration and erythema of the anus may be seen on inspection although more commonly this portion of the examination is unremarkable. A synthesis of 24 studies showed that rectal douching was associated with an almost threefold increased odds of infection with HIV and a more than twofold increase in the risk of a sexually transmitted infection other than HIV Li. A password reset link will be sent to you by email. Mayo Clinic Marketplace Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Untreated, the disease can present in one of several progressive stages—primary chancre or proctitis , secondary condyloma latum, or tertiary. The anal canal is a short tube at the end of your rectum through which stool leaves your body.